L-Teanine - A Supplement to Food for Brains and Mood
L-theanine is a naturally found amino acid that has been shown in some studies to help improve energy levels and reduce stress.
Its effects have been beneficial for thousands of years in Chinese medicine, as well as the latest scientific and clinical research. (Sources at the bottom)
This natural nootropic was originally produced from the "Green Tea" 1949. Since that time, he has been investigated for his ability to support brain health and enhance concentration.
The cognitive effect of L-Theanine is obvious when combined with caffeine, or naturally consumed in green tea. Two-ingredient synergy: caffeine increases the level of vigilance, and Theanine can reduce some of the nervous and anxiety causes that can occur with stimulants.
Before deciding whether or not to use L-Theanine, you may be interested in what it is, published studies, notifications of benefits, how it works, and possible side effects.
What is L-Teanin?
L-teanine (gamma-glutamylethamide) is an analogue of glutamate and glutamine that can pass through the blood brain barrier.
It is a form of L-glutamic acid that can help increase and modulate alpha-brain waves. These brain waves help create feelings of relaxation, relaxation and alertness.
In addition to naturally occurring Camellia Sinensis (green tea), L-Theanine is also found in certain types of mushrooms.
The chemical composition of this substance is similar to the chemical structure of L-tryptophan. This is the precursor of the neurotransmitter serotonin (which helps to influence sleep cycles and relaxation feelings).
Several studies have been conducted to support the benefits of Theanine. The first was 1999 Published by Food Science and Technology Journal. The researchers noted some interesting facts in people receiving 50-200 mg Theanine per week.
Then, their brain waves were measured and it was found that those who received the highest Teanin doses were the most produced alpha brain waves. This allowed them to be more relaxed and daring enough to perform challenging tasks.
Animal studies have shown that this supplement produces higher dopamine concentrations in the brain. 2004 m A study by the Harvard Medical School shows that this supplement also acts as an enhancement to the immune system and helps increase the body's resistance to colds and flu.
Studies have even been performed in chemotherapy patients who received L-Theanine. These results indicate that the supplement helps to concentrate chemicals in unhealthy cells. It can also help reduce the side effects of chemotherapy due to the calming and relaxing effects, although this requires more research.
Food Supplements L-Teanin Benefits
Theanine has many different benefits to mood, cognitive function and general health. The main effect is the overall feeling of relaxation and relaxation. The common sense of well-being and optimism is often the result.
L-Theanine is also the reason why green tea is used to relieve anxiety and nervousness (unlike coffee), despite the fact that green tea contains caffeine. Theanin actually helps to mitigate those caffeine-related side effects, reduces the symptoms of nervousness or restlessness.
In addition, this supplement enhances alpha brain waves. Many consumers say they feel calm, but they know very well that they have a high level of mental alertness and greater clarity and attention. It is a very productive feeling that can reduce stress, reduce worrying thoughts, and even increase motivation.
L-Teanine also has antioxidant effects. This can prevent or reduce LDL cholesterol oxidation.
It has been shown that cardiovascular health improves by promoting the production of nitric oxide (which helps to open the blood vessels) in the arteries. It can also reduce the risk of blood pressure and, in general, cardiovascular disease.
This nutritional supplement can help protect the brain and support better brain cell care. This prevents damage to the neurons by blocking excessive stimulation of the cells and protecting them from low oxygen levels.
Studies also show that it can stimulate the release of specific proteins needed for nerve growth. Due to the increased production of dopamine, Theanine may even play an important role in the treatment of Parkinson's disease, but further studies are needed to confirm the initial results. Read more about dopamine The role of dopamine in the brain - Mood, Attention, Target setting
How Does L-Teanine Work?
Although the specific mechanisms of action of L-Theanine are not fully understood, this material has the potential to cross the blood brain barrier.
It quickly penetrates the bloodstream and is very quick to operate.
Its action begins with the application of various neurotransmitters and their receptors. This includes serotonin, dopamine, GABA and noradrenaline.
It's all powerful brain chemicals that have a great influence on cognitive processes, sleep and relaxation cycles, even pleasure and the brain reward system.
L-Teanine Consumption and Possible Side Effects
There is no known specific side effect associated with this food supplement. However, some users have reported that they experience diarrhea at high doses of Teinalin. Despite the fact that L-Theanine was made with drinking caffeine, such as green tea or coffee, it is the usual way people take this supplement and drink acidity actually caused a gastrointestinal disorder.
This supplement is not recommended for use in combination with high blood pressure medicines; The combination may actually reduce your blood pressure too much. Also, do not take Theanine with stimulants as this will likely reduce their effectiveness. It is always advisable to talk to your doctor before starting any new supplements.
- Tadesse A, Hymete A, Bekhit AA, Mohammed SF. Quantification of total polyphenols, catechin, caffeine, L-theanine, determination of antioxidant activity and effect on antileishmanial drugs of ethiopian tea leaves extracts. Pharmacognosy Res. 2015
- Nunes AR, Alves MG, Moreira PI, Oliveira PF, Silva BM. Can Tea Consumption Be Safe and Effective Therapy Against Diabetes Mellitus-Induced Neurodegeneration? Curr Neuropharmacol. 2014
- Ota M, Wakabayashi C, Sato N, Hori H, Hattori K, Teraishi T, Ozawa H, Okubo T, Kunug H. Effect of l-theanine is a glutamatergic function in patients with schizophrenia. Acta Neuropsychiatr. 2015
- Mu W, Zhang T, Jiang B. An overview of the biological production of L-theanine. Biotechnol Adv. 2015
- Pérez-Vargas JE, Zarco N, Vergara P, Shibayama M, Segovia J, Tsutsumi V, Muriel P. l-Theanine prevents carbon tetrachloride-induced liver fibrosis through inhibition of nuclear factor ÎºB and down-regulation of transforming growth factor Î² and a connective tissue growth factor. Hum Exp Toxicol. 2015
- Dodd FL, Kennedy DO, Riby LM, Haskell-Ramsay CF. A double-blind, placebo-controlled study assessing the effects of caffeine and L-theanine, both alone and in combination, on cerebral blood flow, cognition and mood. Psychopharmacology (Berl). 2015
- Rao TP, Ozeki M, Juneja LR. In Search of Safe Natural Sleep Aid. J Am Coll Nutr. 2015
- Conde VR, Alves MG, Oliveira PF, Silva BM. Tea (Camellia Sinensis (L.)): A Putative Anticancer Agent in Bladder Carcinoma? Anticancer Agents Med Chem. 2014
- Garay RP, Samalin L, Hameg A, Llorca PM. Investigational drugs for anxiety in patients with schizophrenia. Expert Opin Investig Drugs. 2015
- Baker LB, Nuccio RP, Jeukendrup AE. Acute effects of dietary constituents on motor skill and cognitive performance in athletes. Nutr Rev. 2014
- Bindal S, Gupta R. L-theanine synthesis using Ë-glutamyl transpeptidase from Bacillus licheniformis ER-15. J Agric Food Chem. 2014
- Ceremuga TE, Martinson S, Washington J, Revels R, Wojcicki J, Crawford D, Edwards R, Kemper JL, Townsend WL, Herron GM, Ceremuga GA, Padron G, Bentley M. Effects of L-theanine are posttraumatic stress disorder induced changes in rat brain gene expression. ScientificWorldJournal. 2014
- Chatterjee S, Chatterjee A, Roy S, Bera B, Bandyopadhyay SK. L-Theanine healed NSAID-induced gastric ulcer by modulating the pro / antioxidant balance in the gastric ulcer margin. J Nat Med. 2014
- Camfield DA, Stow C, Farrimond J, Scholey AB. Acute effects of tea constituents L-theanine, caffeine, and epigallocatechin gallate are cognitive function and mood: a systematic review and meta-analysis. Nutr Rev. 2014
- Sumathi T, Shobana C, Thangarajeswari M, Usha R. Protective effect of L-Theanine against aluminum induced neurotoxicity in cerebral cortex, hippocampus and cerebellum of rat brain - histopathological and biochemical approach. Drug Chem Toxicol. 2015
- Narukawa M, Toda Y, Nakagita T, Hayashi Y, Misaka T. L-Theanine elicits the umami's taste through the T1R1 + T1R3 Umamy's receptor. Amino Acids. 2014
- Ota M, Wakabayashi C, Matsuo J, Kinoshita Y, Hori H, Hattori K, Sasayama D, Teraishi T, Obu S, Ozawa H, Kunug H. Effect of L-theanine is a sensory motor in healthy human subjects. Psychiatry Clin Neurosci. 2014
- Thangarajan S, Deivasigamani A, Natarajan SS, Krishnan P, Mohanan SK. The neuroprotective activity of L-theanine is 3-nitropropionic acid-induced neurotoxicity in rat striatum. Int J Neurosci. 2014
- Ross SM L-theanine (suntheanin): effects of L-theanine, an amino acid derived from Camellia sinensis (green tea), are stress response parameters. Holist Nurs Pract. 2014
- Yang H, Li W, Yu H, Yuan R, Yang Y, Pung K, Li P, Xue L. The physiological effects of L-theanine are Drosophila melanogaster. Molecules 2013
- Barrett JR, Tracy DK, Giaroli G. To sleep or not to sleep: A systematic review of the literature on pharmacological treatments of insomnia in children and adolescents with attention deficit disorder / hyperactivity disorder. J Child Adolesc Psychopharmacol. 2013
- BaÅŸkan MH, AydÄ ± n M. Electron paramagnetic resonance studies of gamma-irradiated DL-alanine ethyl ester hydrochloride, L-theanine and L-glutamic acid dimethyl ester hydrochloride. Spectrochim Acta A Mol Biomol Spectrosc. 2013
- Tian X, Sun L, Gou L, Ling X, Feng Y, Wang L, Yin X, Liu Y. The protective effect of l-theanine is on chronic restraint stress-induced cognitive impairments in mice. Brain Res 2013
- Schallier A, Vermoosen K, Loyens E, Van Liefferinge J, Michotte Y, Smolders I, Massie A. The L-Theanine intake increases the threshold for limbic seizures but reduces the threshold for generalized seizures. Nutr Neurosci. 2013
- Di-X, Yan J, Zhao Y, Chang Y, Zhao B. L-theanine inhibits nicotine-induced dependence by regulating the nicotine acetylcholine receptor-dopamine reward pathway. Sci China Life Sci. 2012
- Yamamoto S, Kimura T, Tachiki T, Anzai N, Sakurai T, Ushimaru M. The involvement of L-type amino acid transporters in the theinine transport. Biosci Biotechnol Biochem. 2012
- Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake are changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012
- Zukhurova M, Prosvirnina M, Daineko A, Simanenkova A, Petrishchev N, Sonin D, Galagudza M, Shamtsyan M, Juneja LR, Vlasov T. The L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion. Phytother Res. 2013
- Scheid L, Ellinger S, Alteld B, Herholz H, Ellinger J, Henn T, Helfrich HP, Stehle P. The kinetics of L-theanine uptake and metabolism in healthy participants are comparable after ingestion of L-theinine via capsules and green tea. J Nutr 2012
- Wise LE, Premaratne ID, Gamage TF, Lichtman AH, Hughes LD, Harris LS, Aceto MD. L-theanine reduces abstinence in the morphine-dependent rhesus monkeys and elicits anxiolytic-like activity in the mice. Pharmacol Biochem Behav. 2012
- Chen G, Wang Y, Song W, Zhao B, Dou Y. Rapid and selective quantification of L-theanine in ready-to-drink tea from the Chinese market using SPE and UPLC-UV. Food chem 2012
- Siamwala JH, Dias PM, Majumder S, Joshi MK, Sinkar VP, Banerjee G, Chatterjee S. L-theanine promotes nitric oxide production in endothelial cells through eNOS phosphorylation. J Nutr Biochem. 2013
- Jiang W, Gao M, Sun S, Bi A, Xin Y, Han X, Wang L, Yin Z, Luo L. The protective effect of L-theanine is carbon tetrachloride-induced acute hepatic injury in mice. Biochem Biophys Res Commun. 2012
- Zarse K, Jabin S, Ristow M. L-Theanine extends the lifespan of adult Caenorhabditis elegans. Eur J Nutr. 2012
- Foxe JJ, Morie KP, Laud PJ, Rowson MJ, De Bruin EA, Kelly SP. Assessing the effects of caffeine and theanine is the maintenance of vigilance during a sustained attention task. Neuropharmacology. 2012
- Jang HS, Jung JY, Jang IS, Jang KH, Kim SH, Ha JH, Suk K, Lee MG. L-theanine partially counteracts caffeine-induced sleep disturbances in the rat. Pharmacol Biochem Behav. 2012
- Song J, Xu H, Liu F, Feng L. Tea and cognitive health in late life: current evidence and future directions. J Nutr Health Aging. 2012
- Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (SuntheanineÂ®) on objective sleep quality in a boys with attention deficit hyperactivity disorder (ADHD): A randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011
- Li G, Ye Y, Kang J, Yao X, Zhang Y, Jiang W, Gao M, Dai Y, Xin Y, Wang Q, Yin Z, Luo L. l-Theanine prevents alcoholic liver damage through enhancing the antioxidant capability of hepatocytes . Food Chem Toxicol. 2012
- Wakabayashi C, Numakawa T, Ninomiya M, Chiba S, Kunbu H. Behavioral and molecular evidence for psychotropic effects in L-theanine. Psychopharmacology (Berl). 2012
- Vuong QV, Stathopoulos CE, Golding JB, Nguyen MH, Roach PD. Optimal conditions for the extraction of L-theanine from green tea. J Sep Sci. 2011
- Vuong QV, Bowyer MC, Roach PD. L-Theanine: properties, synthesis and isolation from tea. J Sci Food Agric. 2011
- Miodownik C, Maayan R, Ratner Y, Lerner V, Pintov L, Mar M, Weizman A, Ritsner MS. The serum levels of the brain-derived neurotrophic factor and cortisol to sulfate of the dehydroepiandrosterone molar ratio are associated with a clinical response to L-theanine as an augmentation of antipsychotic therapy in schizophrenia and schizoaffective disorder patients. Clin Neuropharmacol. 2011
- Yin C, Gou L, Liu Y, Yin X, Zhang L, Jia G, Zhuang X. Antidepressant-like effects of L-theanine in the forced swim and tail suspension tests in mice. Phytother Res. 2011
- Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS. A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitive impairment: a double-blind, placebo-controlled study. J Med Food. 2011
- Ritsner MS, Miodownik C, Ratner Y, Shleifer T, Mar M, Pintov L, Lerner V. L-theanine relieves positive, activation, and anxiety symptoms in patients with schizophrenia and schizoaffective disorder: an 8-week, randomized, double-blind , placebo-controlled, 2-center study. J Clin Psychiatry. 2011
- Giesbrecht T, Rycroft JA, Rowson MJ, De Bruin EA. The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutr Neurosci. 2010
- L-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity through the inhibition of the NMDA receptor pathway. Neuroscience 2010
- Heese T, Jenkinson J, Love C, Milam R, Perkins L, Adams C, McCall S, Ceremuga TE. Anxiolytic effects of L-theanine - a component of green tea - when combined with midazolam, in the male Sprague-Dawley rat. AANA J. 2009
- Einher SJ, Martens VE, Rycroft JA, De Bruin EA. L-theanine and caffeine improve the task of switching but not intersensory attention or subjective alertness. Appetite 2010
- Kurihara S, Hiraoka T, Akutsu M, Sukegawa E, Bannai M, Shibahara S. Effects of (L) -cystine and (L) -theanine supplementation on a common cold: a randomized, double-blind, and placebo-controlled trial. J Amino Acids. 2010
- Kim TI, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam SY, Yun YW, Han SB, Oh KW, Hong JT. l-Theanine, an amino acid in the green tea, which reduces beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK / p38 kinase and NF-kappaB pathways. Free Radic Biol Med. 2009
- Miyagawa K, Hayashi Y, Kurihara S, Maeda A. Co-administration of l-cystine and l-theanine enhances the efficacy of influenza vaccination in elderly people: nutritional status-dependent immunogenicity. Geriatr Gerontol Int. 2008
- Gomez-Ramirez M, Kelly SP, Montesi JL, Foxe JJ. The effects of L-theanine are alpha-band oscillatory brain activity during a visuo-spatial attention task. Brain Topogr 2009
- Owen GN, Parnell H, De Bruin EA, Rycroft JA. The combined effects of L-theanine and caffeine are cognitive performance and mood. Nutr Neurosci. 2008
- Kelly SP, Gomez-Ramirez M, Montesi JL, Foxe JJ. L-theanine and caffeine in combination affect human cognition as evidenced by the oscillatory alpha-band activity and attention task performance. J Nutr 2008
- Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent of tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008
- Cho HS, Kim S, Lee SY, Park JA, Kim SJ, Chun HS. The protective effect of the green tea component, L-theanine, is environmental toxins-induced neuronal cell death. Neurotoxicology. 2008
- Bukowski JF, Percival SS. L-theanine intervention enhances human gamma deltaT lymphocyte function. Nutr Rev. 2008
- Bryan J. Psychological effects of dietary ingredients of tea: caffeine and L-theanine. Nutr Rev. 2008
- Kurihara S, Shibahara S, Arisaka H, Akiyama Y. Enhancement of antigen-specific immunoglobulin G production in mice by co-administration of L-cystine and L-theanine. J Vet Med Sci. 2007
- Dimpfel W, Kler A, Kriesl E, Lehnfeld R, Keplinger-Dimpfel IK. Source density analysis of the human EEG after ingestion of a drink containing a decaffeinated extract of green tea enriched with L-theanine and theophylline. Nutr Neurosci. 2007
- Dimpfel W, Kler A, Kriesl E, Lehnfeld R. Theogallin and L-theanine as active ingredients in decaffeinated green tea extract: II. Characterization in a freely moving rat using quantitative field potential analysis. J Pharm Pharmacol. 2007
- Dimpfel W, Kler A, Kriesl E, Lehnfeld R. Theogallin and L-theanine as active ingredients in vitamin C of green tea extract: I. Electrophysiological characterization in rat hippocampus in vitro. J Pharm Pharmacol. 2007
- Nathan PJ, Lu K, Gray M, Oliver C. The neuropharmacology of L-theanine (N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006
- Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007
- Borzelleca JF, Peters D, Hall W. A 13-week dietary toxicity and toxicokinetic study with l-theanine in rats. Food Chem Toxicol. 2006
- [No authors listed] L-theanine. Monograph Altern Med Rev. 2005
- Desai MJ, Gill MS, Hsu WH, Armstrong DW. Pharmacokinetics of theanine enantiomers in the rat. Chirality 2005
- Lu K, Gray MA, Oliver C, Liley DT, Harrison BJ, Bartholomew CF, Phan KL, Nathan PJ. The acute effects of L-theanine in comparison with alprazolam are anticipatory anxiety in humans. Hum Psychopharmacol. 2004